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Pipelines consisting of 3 proven technologies in CGT (CAR-T, TCR-T, TIL) targeting Nasopharyngeal/Lung/Liver/Gastrointestinal Cancers, and more
No approved cell immunotherapy for solid tumor to date
Currently, more than half of clinical trials are focusing on blood cancer. However, the larger unmet need and challenge is Solid Tumor.
>90% of all cancer patients with solid tumors
According to the global cancer data of 2021, more than 90% of newly cancer cases worldwide are solid tumor patients, significantly outnumbering patients with blood cancers.
Developing cutting-edge immunotherapies to address unmet needs in oncology
Developing first-in-class (FIC) product against solid tumors
Products in the pipeline are first-in-class (FIC) against solid tumors, focusing on unmet needs globally, well positioned to fill the gap in the market.
Pipelines consisting of 3 proven technologies in CGT (CAR-T, TCR-T, TIL) targeting Nasopharyngeal/Lung/Liver/Gastrointestinal Cancers, and more
TCR-T
  • Biosyngen's Differentiation

    · Next generation design enhancing the persistence of T cells in vivo

    · High affinity/avidity/specificity against tumor specific antigen

  • Biosyngen's Pipeline

    · BRL03: US (IND), CN (IND)

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TIL
  • Biosyngen's Differentiation

    · Able to be cryopreserved to address long distance transportation issue

    · Does not require high dose IL-2 infusion

  • Biosyngen's Pipeline

    · BST02: US (IND), CN (IND)

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CAR-T
  • Biosyngen's Differentiation

    · In-human data showing clinical efficacy

    · Unique target/FIC

    · Enhanced safety profile

  • Biosyngen's Pipeline

    · BRG01: US (IND) and CN (IND), Phase 1 clinical trial concluded in Dec.2023

    · BGT007: Dual CAR-T, IIT in progress

    · ALLO-CEL: In-human by 2024

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Established proprietary technology platforms for R&D translation &
immunotherapy drug development against solid tumors
  • M-CEL

    Automated and intelligent cell manufacturing platform

    M-CEL

    Automated and intelligent cell manufacturing platform

    · Improved production cycle time of CAR-T/TCR-T product to 10-days.


    · Manufactured in GMP facility in compliance to FDA and CDE requirements.

  • SUPER-T

    T cell safety optimization platform

    SUPER-T

    T cell safety optimization platform

    · Unique T cell signaling tweaking strategy and TME-specific promoter to broaden tumor cell coverage while ensuring safety.


  • MSE-T

    T cell functional enhancement platform

    MSE-T

    T cell functional enhancement platform

    · Library consisting of hundreds of motifs for T cell functional enhancement.

  • IDENTIFIER

    Antigen/Antibody/TCR discovery platform

    IDENTIFIER

    Antigen/Antibody/TCR discovery platform

    · Large tumor-specific TCR library for multiple high-frequency HLA haplotypes.


    · Fast screening / optimization.

Global strategy to serve patients worldwide with scalable GMP
production capability and broad clinical network
  • America
    Stanford University School of Medicine

  • France
    Gustave Roussy Cancer Campus

  • Germany
    Helmholtz Zentrum München-German Research Center

  • China
    Sun Yat-sen University Cancer Center

  • Singapore
    The Agency for Science, Technology and Research, Singapore

  • Australia
    QIMR Berghofer Medical Research Institute

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Exclusive Partnership with Public Agencies to pursue breakthrough in development
Abundant clinical resources around the world
  • Clinical trials have been initiated at 8 medical centers in China
  • Clinical trials of NCCS are already ongoing in Singapore
Accelerate R&D progress with cooperative of Top scientific research institutions
  • Sun Yat-sen University Cancer Center: The company is the sole collaborator with SYSUCC for registration of somatic cell therapy clinical trial center in National Health Commission of the PRC.

    Collaboration targets multiple indications . exclusive collaboration in NPC.

    13th Singapore Guangdong Collaboration Council (Jun 2023) – Agreement to set up the Translation Medicine Centre with Guangzhou District Government

Abundant clinical resources around the world
  • Clinical trials have been initiated at 8 medical centers in China
  • Clinical trials of NCCS are already ongoing in Singapore
Accelerate R&D progress with cooperative of Top scientific research institutions
  • Sun Yat-sen University Cancer Center: The company is the sole collaborator with SYSUCC for registration of somatic cell therapy clinical trial center in National Health Commission of the PRC.

    Collaboration targets multiple indications . exclusive collaboration in NPC.

    13th Singapore Guangdong Collaboration Council (Jun 2023) – Agreement to set up the Translation Medicine Centre with Guangzhou District Government

Dual site strategy

Dual site strategy with dual R&D and GMP Facilities to address Global needs

Singapore | Largest private GMP Facility in Singapore
China | The largest GMP Facility in South China
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